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Primary cutaneous neuroblastoma in an old dog
A subcutaneous mass arising in the right gluteal area of an 11-year-old female Shih Tzu dog was surgically excised. One of the most likely clinical differentials is a spindle cell tumor, but histologically the mass was composed of small round or ovoid neoplastic cells that were arranged in nests of various sizes. The neoplastic cells generally had hyperchromatic nuclei and scanty eosinophilic cytoplasm, and were surrounded by a pale pink fibrillar area. A very interesting case and the first description of a neuroblastoma originating from the skin in an adult dog.

Immunohistochemically, the neoplastic cells were positive for vimentin, S-100 protein, neurone-specific enolase and synaptophysin, but negative for cytokeratin, neurofilament protein, glial fibrillary acidic protein and chromogranin A.

On ultrastructural observation, aggregates of thin cytoplasmic processes were frequently seen among the neoplastic cells.

Based on these features, the tumour was diagnosed as a neuroblastoma.

Source: Masaki Michishita, Yuki Momozawa, Takuya Oizumi, Kozo Ohkusu-Tsukada and Kimimasa Takahashi (2010): Primary neuroblastoma in the skin of an adult Shih Tzu dog´. In: Veterinary Dermatology, Early View (Articles online in advance of print)
Published Online: 11 Mar 2010




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SMALL ANIMAL PRACTICE

Reference intervals for blood parameters in Shetland Sheepdogsmembers
Several breeds have physiological peculiarities that induce variations in reference intervals (RIs) compared with the general canine population. Shetland sheepdogs (SSs) are reported to be more predisposed to different diseases (eg, hyperlipidemia, gallbladder mucocele, and hypothyroidism). Consequently, a breed‐specific approach is more often required. Thus, the aim of this study was to determine whether the RIs of the general canine population could be applied to that of SSs, and to generate breed‐specific RIs, where appropriate.

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