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Primary cutaneous neuroblastoma in an old dog
A subcutaneous mass arising in the right gluteal area of an 11-year-old female Shih Tzu dog was surgically excised. One of the most likely clinical differentials is a spindle cell tumor, but histologically the mass was composed of small round or ovoid neoplastic cells that were arranged in nests of various sizes. The neoplastic cells generally had hyperchromatic nuclei and scanty eosinophilic cytoplasm, and were surrounded by a pale pink fibrillar area. A very interesting case and the first description of a neuroblastoma originating from the skin in an adult dog.

Immunohistochemically, the neoplastic cells were positive for vimentin, S-100 protein, neurone-specific enolase and synaptophysin, but negative for cytokeratin, neurofilament protein, glial fibrillary acidic protein and chromogranin A.

On ultrastructural observation, aggregates of thin cytoplasmic processes were frequently seen among the neoplastic cells.

Based on these features, the tumour was diagnosed as a neuroblastoma.

Source: Masaki Michishita, Yuki Momozawa, Takuya Oizumi, Kozo Ohkusu-Tsukada and Kimimasa Takahashi (2010): Primary neuroblastoma in the skin of an adult Shih Tzu dog´. In: Veterinary Dermatology, Early View (Articles online in advance of print)
Published Online: 11 Mar 2010




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SMALL ANIMAL PRACTICE

Aldosterone-producing adrenocortical carcinoma with myxoid differentiation in a Persian cat
A 10‐year‐old male neutered Persian cat was presented with an abdominal mass and history of weakness. Blood smear examination found marked elliptocytosis, and serum biochemical analysis revealed hypokalemia, hypochloremia, increased creatine kinase activity, and a high aldosterone concentration. Cytologic examination of the mass revealed neoplastic endocrine cells with moderate criteria of malignancy, favoring adrenocortical neoplasia. A very interesting case report!

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