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Polycystic meningiomas - clinical and MRI findings
The three retrievers in this case series showed similar clinical signs including seizures, circling, and behavior changes. Neoplasia, metabolic problems or idiopathic epilepsy? None of them, but how could the final diagnosis polycystic meningioma be made in vivo?

One spayed female Labrador retriever and two castrated male golden retrievers were evaluated for chronic (i.e., ranging from 3 wk to 24 wk) neurologic signs localizable to the prosencephalon.

MRI demonstrated extra-axial, contrast-enhancing, multiloculated, fluid-filled, cyst-like lesions with a mass effect, causing compression and displacement of brain parenchyma.

Differential diagnoses included cystic neoplasm, abscess or other infectious cyst (e.g., alveolar hydatid cyst), or fluid-filled anomaly (e.g., arachnoid cyst).

The cyst-like lesions were attached to the rostral falx cerebri in all cases. In addition, case 2 had a second polycystic mass at the caudal diencephalon.

Surgical biopsy (case 3 with a single, rostral tumor via transfrontal craniectomy) and postmortem histology (in cases 1 and 2) confirmed polycystic meningiomas.

Tumor types were transitional (cases 1 and 3) and fibrous (case 2), with positive immunohistochemical staining for vimentin.

Case 3 was also positive for E-cadherin, s100, and CD34.

In all cases, staining was predominantly negative for glial fibrillary acid protein and pancytokeratins, supporting a diagnosis of meningioma.

This report describes the first cases of polycystic meningiomas in dogs.

Polycystic meningiomas are a rare, but important, addition to the differential diagnoses for intracranial cyst-like lesions, significantly affecting planning for surgical resection and other therapeutic interventions.


Source: Fiona M. K. James, Ronaldo C. da Costa, Amy Fauber, Andrew S. Peregrine, Beverly McEwen, Joane M. Parent, Robert Bergman (2012): Clinical and MRI Findings in Three Dogs with Polycystic Meningiomas. In: Published online before print July 27, 2012, doi: 10.5326/JAAHA-MS-5774
Journal of the American Animal Hospital Association Sep/Oct 2012 jaaha.5774




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SMALL ANIMAL PRACTICE

3 Serological Tests for Early Detection Of Leptospira-specific Antibodies
Leptospirosis in dogs is a disease of global importance. Early detection and appropriate therapeutic intervention are necessary to resolve infection and prevent zoonotic transmission. However, its diagnosis is hindered by nonspecific clinical signs and lack of rapid diagnostic tests of early infection. Recently, 2 rapid point-of-care tests (WITNESS Lepto [WITNESS Lepto, Zoetis LLC, Kalamazoo, MI, USA] and SNAP Lepto [SNAP Lepto, IDEXX Laboratories, Westbrook, ME, USA]) for detection of Leptospira-specific antibodies in canine sera were developed. This recently online published article compares three systems for early diagnosis.

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