Home
http://www.virbac.fr/ http://www.boehringer-ingelheim.com/ http://www.novartis.com/ http://www.animalhealth.bayerhealthcare.com/
vetcontact
Vetrinr
Tiermedizin
  WELCOME  
vetcontact
Vetrinr
Tiermedizin
  Home  
  Login / Newsletter  
vetcontact
Vetrinr
Tiermedizin
  CONTACTS  
vetcontact
Vetrinr
Tiermedizin
  Classifieds  
  New Products  
  VetCompanies  
  VetSchools  
vetcontact
Vetrinr
Tiermedizin
  PROFESSION  
vetcontact
Vetrinr
Tiermedizin
  Edutainment  
  VetAgenda  
  Presentations  
  Posters  
  ESAVS  
  Specialisation  
vetcontact
Vetrinr
Tiermedizin
  INSIGHT  
vetcontact
Vetrinr
Tiermedizin
  Congress News  
  Picture Galleries  
vetcontact
Vetrinr
Tiermedizin
  PRODUCTS  
vetcontact
Vetrinr
Tiermedizin
  Bayer  
  Boehringer Ing.  
  Novartis  
  Virbac

 
  Simply book for less...  
    

Bovine    Equine    Small Animal Practice    Swine Practice    Articles    Vetjournal    
deutsch english espaol polski francais
Home / WELCOME / Archiv / Small Animal Practice /     
 
Comparison of different insulin protocols for type 2 diabetes
Many patients with type 2 diabetes mellitus (T2DM) initiate insulin therapy when other treatments fail; how best to do this is poorly defined. People with T2DM [n = 588; glycated haemoglobin A1C (A1C) >7.0%, mean baseline 9.4%] were randomized to twice-daily premixed protamine-aspart/aspart insulin (PM − 2), once-daily insulin glargine plus zero to one prandial insulin glulisine injection (G + 1), or insulin glargine plus zero to three prandial injections (G + 3). Insulin was titrated for 60 weeks. Efficacy and safety outcomes were assessed. A very interesting human Investigation!

Discontinuation rates were 53 of the 194 (27%), 44 of the 194 (23%) and 38 of the 194 (20%), for PM − 2, G + 1 and G + 3.

Glycaemic control improved in all groups (A1C 7.2 ± 1.37, 7.1 ± 1.68 and 7.0 ± 1.21% at 60 weeks; 7.5 ± 1.29, 7.2 ± 1.62 and 7.2 ± 1.63% at endpoint).

G + 1 was statistically non-inferior to PM − 2 in reducing A1C.

G + 3 was slightly superior to PM − 2 in attaining <7.0% at 60 weeks, but only when the analysis included Good Clinical Practice non-adherent sites.

Hypoglycaemia with plasma glucose <2.8 mmol/l was more frequent with PM − 2 versus G + 1 and G + 3; [adjusted incidence: 46 (p = 0.0087) vs. 33 (p = 0.0045) and 31.5%; events per patient-year: 1.9 vs. 0.8 and 0.9, p ≤ 0.0001].

Insulin dosage and weight-gain were similar.

Basal insulin plus a single prandial injection is as effective in improving glycaemic control as premixed insulin.

Full basal-prandial therapy is only slightly more effective than premixed insulin.

Stepwise basal-prandial regimens improve glycaemic control with less hypoglycaemia than twice-daily premixed insulin.


Source: Riddle, M. C., Rosenstock, J., Vlajnic, A. and Gao, L. (2014), Randomized, 1-year comparison of three ways to initiate and advance insulin for type 2 diabetes: twice-daily premixed insulin versus basal insulin with either basal-plus one prandial insulin or basal-bolus up to three prandial injections. Diabetes, Obesity and Metabolism, 16: 396–402. doi: 10.1111/dom.12225


Tell a friend   |   Print version   |   Send this article

SMALL ANIMAL PRACTICE

Electroretinography as a prognostic indicator after retinal reattachment surgery
Retinal detachment is one of the ophthalmological emergencies, and even if the diagnosis is made early and a reattachment surgery is performed immediately many dogs do not regain postoperative vision. This 18‐month prospective study recorded signalment, duration, cause, and extent of retinal detachment and pre‐operative vision status. Rod and mixed rod‐cone ERG responses were recorded prior to RRS. Referring veterinary ophthalmologists assessed vision 2 months postoperatively to determine whether pre‐operative electroretinography (ERG) predicts postoperative vision in dogs undergoing retinal reattachment surgery (RRS).

  • Computed tomographic lymphography for lymph node staging in dogs with malignant tumors members
  • Characterization of ocular melanosis-affected canine melanocytesmembers
  • Nasopharyngeal sialoceles in brachycephalic dogsmembers
  • Enterococcus faecium SF68 on serum cobalamin and folate concentrationsmembers
  • Gastrointestinal eosinophilic sclerosing fibroplasia limited to the mesentery in a catmembers
  • Ion acid-base disturbances and associated mortality in dogsmembers
  • First description of ultrasonic bone curette in canine otic surgerymembers
  • Staining hair samples with a modified Wright-Giemsa stain to diagnose feline dermatophytosismembers
  • Oral extended release hydrocodone as analgesia after TPLOmembers
  • 25OH vitamin D3 serum concentration in dogs with acute polyradiculoneuritismembers
  • Type 1 immune mediated polyarthritis in dogs and temporal relationship to vaccination members
  • Phosphorus and protein supply before diagnosis of chronic kidney disease members


  • [ Home ] [ About ] [ Contact / Request ][ Disclaimer ]

    Copyright © 2001-2016 VetContact GmbH
    All rights reserved