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Ocular hypertension-induced retinal ischemia-reperfusion injury
This recently published study was performed to
evaluate for drugs with superior neuroprotective efficacy and investigate their underlying mechanisms related to antioxidation. Brinzolamide (1%), timolol (0.5%), minocycline (22 mg/kg), lidocaine (1.5 mg/kg), and methylprednisolone (30 mg/kg) were administered to Sprague-Dawley (SD) rats.

The retina was evaluated by electroretinography and histological analysis.

The antioxidative capacity of drugs was evaluated to clarify the underlying mechanism.

The oxidant/antioxidant profiles of plasma, red blood cells, and retina were analyzed by lipid peroxidation (malondialdehyde) and by measuring the activities of antioxidants.

Proteomic analysis was used to investigate the possible protective mechanisms of the drug against ischemia-reperfusion injury.

The results suggested that timolol, methylprednisolone, and minocycline protected retinal function.

Methylprednisolone and minocycline possessed good antioxidative activity.

Brinzolamide and lidocaine preserved the structural integrity of the retina, but not retinal function.

Methylprednisolone, minocycline, and timolol have potential acute or delayed benefit in retinal ischemia-reperfusion injury.

Their neuroprotective actions depend at least partially on the ability to alleviate oxidative stress.




Source: Chen, Y.-I., Lee, Y.-J., Wilkie, D. A. and Lin, C.-T. (2014), Evaluation of potential topical and systemic neuroprotective agents for ocular hypertension-induced retinal ischemia-reperfusion injury. Veterinary Ophthalmology, 17: 432–442. doi: 10.1111/vop.12105


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SMALL ANIMAL PRACTICE

Patient-specific facemask to facilitate brain biopsymembers
The objective of this pilot study was to describe the application and first preliminary data of a novel MRI and CT compatible patient-specific facemask for stereotactic brain biopsy of intracranial lesions in dogs. Five client-owned dogs presenting for neurological deficits consistent with forebrain disease were included in the study. All dogs had MRI findings consistent with an intracranial lesion. But biopsies in this region are not easy to obtain. Does an individual face mask help?

  • Critically ill dogs and their immune function
  • RET-He to diagnose iron-deficient erythropoiesis in dogsmembers
  • Hypertriglyceridemia-Associated Proteinuria in Miniature Schnauzersmembers
  • Gastrointestinal dysmotility disorders in critically ill animalsmembers
  • Disorder of sex development in a cat with chromosome mosaicism members
  • Generalized discoid lupus erythematosus in dogs members
  • Epidermolysis bullosa acquisita in dogsmembers
  • Chiari-Like Malformation and Syringomyelia in American Brussels Griffon Dogsmembers
  • Efficacy and Potential Complications of Transjugular Liver Biopsymembers
  • Hypomagnesemia in Brachycephalic Dogsmembers
  • Comparison of two minimally invasive techniques for liver biopsy members
  • Topical aqueous sirolimus and the tear production members


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