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Ocular hypertension-induced retinal ischemia-reperfusion injury
This recently published study was performed to
evaluate for drugs with superior neuroprotective efficacy and investigate their underlying mechanisms related to antioxidation. Brinzolamide (1%), timolol (0.5%), minocycline (22 mg/kg), lidocaine (1.5 mg/kg), and methylprednisolone (30 mg/kg) were administered to Sprague-Dawley (SD) rats.

The retina was evaluated by electroretinography and histological analysis.

The antioxidative capacity of drugs was evaluated to clarify the underlying mechanism.

The oxidant/antioxidant profiles of plasma, red blood cells, and retina were analyzed by lipid peroxidation (malondialdehyde) and by measuring the activities of antioxidants.

Proteomic analysis was used to investigate the possible protective mechanisms of the drug against ischemia-reperfusion injury.

The results suggested that timolol, methylprednisolone, and minocycline protected retinal function.

Methylprednisolone and minocycline possessed good antioxidative activity.

Brinzolamide and lidocaine preserved the structural integrity of the retina, but not retinal function.

Methylprednisolone, minocycline, and timolol have potential acute or delayed benefit in retinal ischemia-reperfusion injury.

Their neuroprotective actions depend at least partially on the ability to alleviate oxidative stress.




Source: Chen, Y.-I., Lee, Y.-J., Wilkie, D. A. and Lin, C.-T. (2014), Evaluation of potential topical and systemic neuroprotective agents for ocular hypertension-induced retinal ischemia-reperfusion injury. Veterinary Ophthalmology, 17: 432–442. doi: 10.1111/vop.12105


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SMALL ANIMAL PRACTICE

Storage temperatures and container types and the urine protein : creatinine ratios
Preanalytic protein adsorption to polymer and glass container surfaces may decrease urine protein concentration measurements and urine protein: creatinine ratios (UPC). Does urine stored in PC or glass containers have lower UPC than urine stored in HP containers? The specific objective was to determine whether clinically relevant differences in UPC would be detected after storage in glass, PC, or HP containers using common storage times and temperatures. Twelve client‐owned dogs with proteinuria helped to answer these important questions.

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