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3D-CRT in dogs with massive hepatocellular carcinoma
Hepatic tumors often are either too big for surgical resection or the owner decline this operation. This recently online published study evaluates the activity and tolerability of three-dimensional conformal radiation therapy (3D-CRT) in six dogs with massive hepatocellular carcinoma.

Six dogs with massive hepatocellular carcinoma that were ineligible for surgical resection or with owners who declined surgical resection, and underwent 3D-CRT were retrospectively reviewed.

6 to 10 Gy per fraction was prescribed at isocentre of planning target volume to a total dose of 18 to 42 Gy with 1 to 2 fractions per week for a total of 3 to 7 fractions.

Follow-up examinations included physical examination, contrast-enhanced CT scan and blood analysis (complete blood count, electrolytes and serum biochemical panel).

The median follow-up time after 3D-CRT was 534 (range, 281 to 1057) days.

An objective response was observed in five of six cases.

Radiation-induced liver disease developed in one dog but was asymptomatic and reversible.

Toxicity was not noted in any other dog.

3D-CRT appears to be a viable treatment option for dogs with inoperable massive hepatocellular carcinoma.


Source: Mori, T., Ito, Y., Kawabe, M., Iwasaki, R., Sakai, H., Murakami, M. and Maruo, K. (2015), Three-dimensional conformal radiation therapy for inoperable massive hepatocellular carcinoma in six dogs. Journal of Small Animal Practice, 56: 441–445. doi: 10.1111/jsap.12352




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SMALL ANIMAL PRACTICE

Storage temperatures and container types and the urine protein : creatinine ratios
Preanalytic protein adsorption to polymer and glass container surfaces may decrease urine protein concentration measurements and urine protein: creatinine ratios (UPC). Does urine stored in PC or glass containers have lower UPC than urine stored in HP containers? The specific objective was to determine whether clinically relevant differences in UPC would be detected after storage in glass, PC, or HP containers using common storage times and temperatures. Twelve client‐owned dogs with proteinuria helped to answer these important questions.

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