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3D-CRT in dogs with massive hepatocellular carcinoma
Hepatic tumors often are either too big for surgical resection or the owner decline this operation. This recently online published study evaluates the activity and tolerability of three-dimensional conformal radiation therapy (3D-CRT) in six dogs with massive hepatocellular carcinoma.

Six dogs with massive hepatocellular carcinoma that were ineligible for surgical resection or with owners who declined surgical resection, and underwent 3D-CRT were retrospectively reviewed.

6 to 10 Gy per fraction was prescribed at isocentre of planning target volume to a total dose of 18 to 42 Gy with 1 to 2 fractions per week for a total of 3 to 7 fractions.

Follow-up examinations included physical examination, contrast-enhanced CT scan and blood analysis (complete blood count, electrolytes and serum biochemical panel).

The median follow-up time after 3D-CRT was 534 (range, 281 to 1057) days.

An objective response was observed in five of six cases.

Radiation-induced liver disease developed in one dog but was asymptomatic and reversible.

Toxicity was not noted in any other dog.

3D-CRT appears to be a viable treatment option for dogs with inoperable massive hepatocellular carcinoma.


Source: Mori, T., Ito, Y., Kawabe, M., Iwasaki, R., Sakai, H., Murakami, M. and Maruo, K. (2015), Three-dimensional conformal radiation therapy for inoperable massive hepatocellular carcinoma in six dogs. Journal of Small Animal Practice, 56: 441–445. doi: 10.1111/jsap.12352




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SMALL ANIMAL PRACTICE

Patient-specific facemask to facilitate brain biopsymembers
The objective of this pilot study was to describe the application and first preliminary data of a novel MRI and CT compatible patient-specific facemask for stereotactic brain biopsy of intracranial lesions in dogs. Five client-owned dogs presenting for neurological deficits consistent with forebrain disease were included in the study. All dogs had MRI findings consistent with an intracranial lesion. But biopsies in this region are not easy to obtain. Does an individual face mask help?

  • RET-He to diagnose iron-deficient erythropoiesis in dogsmembers
  • Hypertriglyceridemia-Associated Proteinuria in Miniature Schnauzersmembers
  • Gastrointestinal dysmotility disorders in critically ill animalsmembers
  • Disorder of sex development in a cat with chromosome mosaicism members
  • Generalized discoid lupus erythematosus in dogs members
  • Epidermolysis bullosa acquisita in dogsmembers
  • Chiari-Like Malformation and Syringomyelia in American Brussels Griffon Dogsmembers
  • Efficacy and Potential Complications of Transjugular Liver Biopsymembers
  • Hypomagnesemia in Brachycephalic Dogsmembers
  • Comparison of two minimally invasive techniques for liver biopsy members
  • Topical aqueous sirolimus and the tear production members
  • JAK 1/2 inhibitor in the treatment of canine B-cell lymphomamembers


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