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CRP to differentiate pyometra from cystic endometrial hyperplasia
Pyometra is one of the common emergencies in small animal practice, often requiring immediate (surgical) intervention. On the other hand, cystic endometrial hyperplasia is an important differential diagnosis, but the differentiation of both can be a problem. A group from Sweden tried a very popular parameter in human medicine, C-reactive protein, to differentiate both problems.

Hematological parameters, plasma C-reactive protein (CRP), and tumor necrosis factor were analyzed in 64 dogs with a presumptive diagnosis of pyometra.
Final diagnosis (i.e., pyometra or cystic endometrial hyperplasia [CEH]) was determined by histopathology.

As a single test, the percentage of band neutrophils had the highest sensitivity in the prediction of pyometra (sensitivity, 94%). The combination of percentage of bands and CRP had the highest sensitivity (97.7%; specificity, 75%) in predicting the presence of pyometra. The most common clinical signs noted in the study were vaginal discharge, polyuria, polydipsia, lethargy, and gastrointestinal signs.

A combination of three or more of these clinical signs was significantly associated with pyometra.

Source: Boel A. Fransson, Erika Karlstam, Annika Bergstrom, Anne-Sofie Lagerstedt, Jean S. Park, Marc A. Evans and Claude A. Ragle (2004): C-reactive Protein in the Differentiation of Pyometra From Cystic Endometrial Hyperplasia/Mucometra in Dogs. In: Journal of the American Animal Hospital Association 40:391-399 (2004)







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SMALL ANIMAL PRACTICE

Shock index in identifying acute blood loss in healthy dogs
Does the shock index (SI) increase following blood donation and is it a more sensitive assessment of acute blood loss as heart rate (HR), blood pressure, and plasma Lactate? An interesting question! 20 client-owned clinically normal dogs were enrolled in this prospective study.

  • Patient-specific facemask to facilitate brain biopsymembers
  • RET-He to diagnose iron-deficient erythropoiesis in dogsmembers
  • Hypertriglyceridemia-Associated Proteinuria in Miniature Schnauzersmembers
  • Gastrointestinal dysmotility disorders in critically ill animalsmembers
  • Disorder of sex development in a cat with chromosome mosaicism members
  • Generalized discoid lupus erythematosus in dogs members
  • Epidermolysis bullosa acquisita in dogsmembers
  • Chiari-Like Malformation and Syringomyelia in American Brussels Griffon Dogsmembers
  • Efficacy and Potential Complications of Transjugular Liver Biopsymembers
  • Hypomagnesemia in Brachycephalic Dogsmembers
  • Comparison of two minimally invasive techniques for liver biopsy members
  • Topical aqueous sirolimus and the tear production members


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