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Chlorambucil-induced myoclonus in a cat
Chlorambucil is a very popular drug in feline medicine, especially used in the treatment of autoimmune diseases like pemphigus foliaceus or in neoplastic conditions like lymphoma. Neurotoxicity as a common side effect like in human medicine has never been described - until this cat was treated with chlorambucil.

Chlorambucil is an alkylating agent. Neurotoxicity has been well recognized in human patients. Onsets of central nervous system signs, such as myoclonus, tremors, muscular twitching, agitation, and tonic-clonic seizures, have been reported in humans and laboratory animals treated with chlorambucil.

This case of a cat with intestinal lymphoma represents the first veterinary patient reported to have chlorambucil-induced neurotoxicity.

Therefore, neurotoxicity should be considered a potential side effect of chlorambucil therapy also in veterinary patients.

Source: Noémi Benitah, Louis-Philippe de Lorimier, Michele Gaspar, Barbara E. Kitchell (2003): Chlorambucil-Induced Myoclonus in a Cat With Lymphoma. In: Journal of the American Animal Hospital Association 39:283-287 (2003)





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SMALL ANIMAL PRACTICE

Reference intervals for blood parameters in Shetland Sheepdogsmembers
Several breeds have physiological peculiarities that induce variations in reference intervals (RIs) compared with the general canine population. Shetland sheepdogs (SSs) are reported to be more predisposed to different diseases (eg, hyperlipidemia, gallbladder mucocele, and hypothyroidism). Consequently, a breed‐specific approach is more often required. Thus, the aim of this study was to determine whether the RIs of the general canine population could be applied to that of SSs, and to generate breed‐specific RIs, where appropriate.

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