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Chlorambucil-induced myoclonus in a cat
Chlorambucil is a very popular drug in feline medicine, especially used in the treatment of autoimmune diseases like pemphigus foliaceus or in neoplastic conditions like lymphoma. Neurotoxicity as a common side effect like in human medicine has never been described - until this cat was treated with chlorambucil.

Chlorambucil is an alkylating agent. Neurotoxicity has been well recognized in human patients. Onsets of central nervous system signs, such as myoclonus, tremors, muscular twitching, agitation, and tonic-clonic seizures, have been reported in humans and laboratory animals treated with chlorambucil.

This case of a cat with intestinal lymphoma represents the first veterinary patient reported to have chlorambucil-induced neurotoxicity.

Therefore, neurotoxicity should be considered a potential side effect of chlorambucil therapy also in veterinary patients.

Source: Noémi Benitah, Louis-Philippe de Lorimier, Michele Gaspar, Barbara E. Kitchell (2003): Chlorambucil-Induced Myoclonus in a Cat With Lymphoma. In: Journal of the American Animal Hospital Association 39:283-287 (2003)





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SMALL ANIMAL PRACTICE

Brachycephalic airway syndrome - differences between pugs and French bulldogs
Does the brachycephalic airway syndrome mean the same in all brachycephalic breeds or are there breed-specific differences? A fascinating question was raised. This retrospective study including 72 dogs aimed to compare clinical features of brachycephalic airway syndrome and long-term surgical outcomes between pugs and French bulldogs and evaluate the influence of laryngeal collapse.

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