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Non-coherent light - a good alternative in treatment of superficial tumours?
Light therapy is very popular in human medicine and getting more important also in animals. So this brandnew study measures the effect of a 665-nm red light from a non-coherent light source or a dye laser in the treatment of superficial tumours. The result: surprising!

Cultured 9L cells were incubated with varying concentrations of pheophorbide-a-hexyl ether (HPPH) and then exposed to 665-nm red light from a non-coherent light source or a dye laser.

Cell death was produced by both light sources, with the non-coherent light being most effective at the highest HPPH concentrations. To assess the feasibility of using the non-coherent light source for clinical photodynamic therapy (PDT), four dogs and three cats presenting with spontaneous superficial tumours were injected intravenously with 0.15 mg kg1 of HPPH, 1 h before their tumours were irradiated with 665-nm non-coherent light (50 mW cm2, 100 J cm2).

Of the nine tumours treated, there were eight complete responses, all occurring in animals with squamous cell carcinoma. After 68 weeks of follow-up, the median initial disease-free interval had not been reached.

These data suggest that non-coherent light sources may be efficacious for photodynamic therapy of spontaneous superficial tumours in animals, representing a cost-effective alternative to medical lasers in both veterinary and human oncology.


Source: Reeds, K. B., Ridgway, T. D., Higbee, R. G. & Lucroy, M. D. (2004): Non-coherent light for photodynamic therapy of superficial tumours in animals. In: Veterinary and Comparative Oncology 2 (3), 157-163.




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SMALL ANIMAL PRACTICE

Reference intervals for blood parameters in Shetland Sheepdogsmembers
Several breeds have physiological peculiarities that induce variations in reference intervals (RIs) compared with the general canine population. Shetland sheepdogs (SSs) are reported to be more predisposed to different diseases (eg, hyperlipidemia, gallbladder mucocele, and hypothyroidism). Consequently, a breed‐specific approach is more often required. Thus, the aim of this study was to determine whether the RIs of the general canine population could be applied to that of SSs, and to generate breed‐specific RIs, where appropriate.

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