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Secondary hypercalcemia due to iatrogenic Cushing in a cat
Cats are known to have a much higher corticosteroid-tolerance than other species, especially dogs. But it is also possible to cause severe metabolic aberrations with chronic parenteral corticosteroid applications in this species, as this very impressive case report shows.

A 9-year-old, spayed female domestic shorthair cat presented for polyphagia, polydipsia, and polyuria following chronic methylprednisolone acetate therapy for pruritus.

Initial diagnostics were consistent with uncomplicated diabetes mellitus. Serum calcium was within reference range.

Within 12 hours the cat developed depression, anorexia, vomiting, and severe dehydration. Laboratory analysis indicated marked hypercalcemia as measured by both ionized and total calcium concentration. No underlying neoplastic or inflammatory process was identified.

An adrenocorti-cotropic hormone stimulation test was indicative of adrenocortical insufficiency. The hypercalcemia resolved with glucocorticoid supplementation and correction of the dehydration.

The diabetes mellitus and adrenal insufficiency both resolved within 9 weeks.



Source: Stephanie A. Smith, Lisa C. Freeman, Mary Bagladi-Swanson (2002): Hypercalcemia Due to Iatrogenic Secondary Hypoadrenocorticism and Diabetes Mellitus in a Cat. In: Journal of the American Animal Hospital Association 38:41-44 (2002)



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SMALL ANIMAL PRACTICE

Reference intervals for blood parameters in Shetland Sheepdogsmembers
Several breeds have physiological peculiarities that induce variations in reference intervals (RIs) compared with the general canine population. Shetland sheepdogs (SSs) are reported to be more predisposed to different diseases (eg, hyperlipidemia, gallbladder mucocele, and hypothyroidism). Consequently, a breed‐specific approach is more often required. Thus, the aim of this study was to determine whether the RIs of the general canine population could be applied to that of SSs, and to generate breed‐specific RIs, where appropriate.

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