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Secondary hypercalcemia due to iatrogenic Cushing in a cat
Cats are known to have a much higher corticosteroid-tolerance than other species, especially dogs. But it is also possible to cause severe metabolic aberrations with chronic parenteral corticosteroid applications in this species, as this very impressive case report shows.

A 9-year-old, spayed female domestic shorthair cat presented for polyphagia, polydipsia, and polyuria following chronic methylprednisolone acetate therapy for pruritus.

Initial diagnostics were consistent with uncomplicated diabetes mellitus. Serum calcium was within reference range.

Within 12 hours the cat developed depression, anorexia, vomiting, and severe dehydration. Laboratory analysis indicated marked hypercalcemia as measured by both ionized and total calcium concentration. No underlying neoplastic or inflammatory process was identified.

An adrenocorti-cotropic hormone stimulation test was indicative of adrenocortical insufficiency. The hypercalcemia resolved with glucocorticoid supplementation and correction of the dehydration.

The diabetes mellitus and adrenal insufficiency both resolved within 9 weeks.



Source: Stephanie A. Smith, Lisa C. Freeman, Mary Bagladi-Swanson (2002): Hypercalcemia Due to Iatrogenic Secondary Hypoadrenocorticism and Diabetes Mellitus in a Cat. In: Journal of the American Animal Hospital Association 38:41-44 (2002)



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SMALL ANIMAL PRACTICE

Oral extended release hydrocodone as analgesia after TPLOmembers
Tibial plateau leveling osteotomy (TPLO) is a very popular technique to treat ruptured cranial cruciate ligaments in dogs, and it requires a balanced analgesia regimen after surgery. The aim of this study was to determine the efficacy of oral extended‐release hydrocodone compared with oral firocoxib for analgesia following tibial plateau leveling osteotomy surgery in dogs in a hospital setting.

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