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Mutation associated with factor XI deficiency in Holstein cattle
A deficiency of blood coagulation factor XI is known to occur not only in small animals but also in large animals, especially in Holstein cattle. Recently, a mutation leading to this defect could be discovered - and it might be more common in the USA Holstein sires than previously thought.

An autosomal recessive deficiency of blood coagulation factor XI (FXI) has been described in Holstein cattle.

Current testing methods are unsuitable for accurately identifying carriers (heterozygotes) of the disease.

To identify the molecular basis of this deficiency, a polymerase chain reaction (PCR)-based strategy was implemented to clone and sequence the bovine FXI gene (F11) from animals of different genotypes.
Approximately 14 kb of genomic DNA sequence and 1.8 kb of cDNA sequence, corresponding to exon 3 through the 3`-UTR, of the bovine gene were obtained.

Comparison of sequences derived from homozygous normal and deficient individuals revealed that FXI deficiency in Holsteins is associated with the insertion of a 76 bp segment [AT(A)28TAAAG(A)26GGAAATAATAATTCA] within exon 12.
This insertion introduces a stop codon that results in a mature FXI protein lacking the functional protease domain encoded by exons 13, 14 and 15.

Based on these data, a DNA-based diagnostic test has been developed for accurate genotyping.

Using this method, the frequency of the mutated allele has been determined to be 1.2% in a contemporary population of the USA Holstein sires.



Source: Marron, B. M., Robinson, J. L., Gentry, P. A. & Beever, J. E. (2004): Identification of a mutation associated with factor XI deficiency in Holstein cattle. In: Animal Genetics 35 (6), 454-456.












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BOVINE

Growth factor expression in cows with cystic ovarian diseasemembers
The objective of the present study was to examine the expression of transforming growth factor beta receptor (TGFBR)1, TGFBR2, TGFBR3, Activin Receptor (ACVR)1B and ACVR2B in ovaries of cows with Cystic Ovarian Disease (COD). The expression of the selected receptors was determined by immunohistochemistry in sections of ovaries from cows with ACTH‐induced and spontaneous COD. A very interesting study which maybe offers new therapeutic options in future.

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