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Immunohistochemistry in dogs with VKH-like syndrome
Vogt-Koyanagi-Harada (VKH)-like syndrome or uveodermatological syndrome (UVD) occurs in certain breeds and is characterized by a severe autoaggression directed against melanocytes. This brandnew study of tissues of 2 dogs shows very interesting news - the cell response of eye and skin is different which might explain the clinical difference in the level of inflammation!

Ocular and cutaneous tissues from two Japanese Akita dogs with uveodermatologic syndrome were subjected to immunohistochemical analysis.

Results: Light microscopic examination of the globes confirmed the presence of panuveitis of different severity in each case.

The infiltrate was primarily granulomatous with prominent perivascular lymphoid aggregates. Melanophages were present throughout the affected areas, and there were scattered plasma cells. Immunohistochemistry using CD79a, CD3, MAC387 and MHC class II markers indicated that there were relatively few T lymphocytes and that most lymphocytes were of the B-cell lineage.

The two skin biopsies examined also appeared to represent different stages of cutaneous pathology.
The biopsy from one case was consistent with the reported features of skin lesions of canine UVD syndrome, including granulomatous dermatitis with extensive T-cell infiltration extending into the epidermis.

In contrast, the skin lesion from the second case showed less inflammation, more pigmentary incontinence and evidence of dermal fibrosis. There was no immunoglobulin or complement deposition at any level within the cutaneous or ocular lesions.

The findings of these two cases suggest that the skin lesions of these two dogs with UVD syndrome were mediated by T cells and macrophages (Th1 immunity), whereas the ocular lesions were more consistent with a B cell and macrophage response (Th2 immunity).

This is, however, a preliminary investigation and these features may not be the same for all cases of UVD syndrome.


Source: Carter, Wallace J., Crispin, Sheila M., Gould, David J. & Day, Michael J. (2005): An immunohistochemical study of uveodermatologic syndrome in two Japanese Akita dogs. In: Veterinary Ophthalmology 8 (1), 17-24.




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