|The aim of the present study was to show the efficacity as well as side the effects of the combined use of the dopamine agonist cabergoline # and the prostaglandin F 2√°analogue alfaprostol # for terminating unwanted pregnancies in the bitch.
The animals were randomly assigned to 4 treatment groups: group A ¬Ė 20√¨g alfaprostol/kg body weight (BW) and 5 √¨g cabergoline/kg BW; group B ¬Ė 10 √¨g alfaprostol/kg BW and 5√¨g cabergoline/kg BW; group C ¬Ė 5 √¨g alfaprost/kg BW and 5 √¨g cabergline/kg BW ; group D ¬Ė 1√¨g cloprostenol/kg BW and 5 √¨g cabergoline/kg BW.
The owner administered oral doses of cabergoline daily and a veterinarian injected the PGF2√°-agonist intramuscularly every second day in the clinic.
Treatment terminated pregnancy in all dogs (n = 20): 2 of them exhibited abortion, 6 bitches showed abortion of some foetuses as well as resorption of the remaining ones, but resorption of all foetuses took place in 12 cases. Side effects of the treatment decreased with reduced alfaprostol dose.
All group-A bitches vomited after each application of alfaprostol, in contrast to group C: 2 animals showed no side effects and only one bitch vomited after each treatment. Side effects were also alleviated in group B, when compared with group A.
In general, the animals responded to cloprostenol by exhibiting more serious side effects (group D) than in all other groups. Combined application of 5 √¨g alfaprostol/kg BW and 5 √¨g cabergoline/kg BW is able to terminate unwanted pregnancies in the bitch.
Treatment can be started when pregnancy is first detected by sonography. Advantages of the use of the tested medication in veterinary practice are high efficacity as well as mild side effects.
Tell a friend
Send this article
Oral extended ¬źrelease hydrocodone as analgesia after TPLO25¬źOH vitamin D3 serum concentration in dogs with acute polyradiculoneuritisType 1 immune mediated polyarthritis in dogs and temporal relationship to vaccination Phosphorus and protein supply before diagnosis of chronic kidney disease Bilateral retinoschisis in a Labrador retrieverWater requirements of canine athletes during exercise over daysPredictors of Sudden Cardiac Death in Doberman Pinschers with DCMD-dimer concentration after soft tissue and orthopedic surgery Canine oral mucosa as autograft in unresponsive keratoconjunctivitis siccaComputed tomographic findings in dogs infected with Crenosoma vulpisPredicting histopathological classification of canine mammary carcinomas via sonographyThe expression of Vitamin D receptors in dogs