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Combination of PGF2alpha analogues with cabergoline to stop early pregnancy in bitches
Unwanted pregnancies in dogs are commonly seen in small animal practice. For many years they were stopped with estrogen - a therapy including high risks for the bitch, even sometimes ending fatally. How effective and safe is the `newest` alternative??

The aim of the present study was to show the efficacity as well as side the effects of the combined use of the dopamine agonist cabergoline # and the prostaglandin F 2√°analogue alfaprostol # for terminating unwanted pregnancies in the bitch.

The animals were randomly assigned to 4 treatment groups: group A ¬Ė 20√¨g alfaprostol/kg body weight (BW) and 5 √¨g cabergoline/kg BW; group B ¬Ė 10 √¨g alfaprostol/kg BW and 5√¨g cabergoline/kg BW; group C ¬Ė 5 √¨g alfaprost/kg BW and 5 √¨g cabergline/kg BW ; group D ¬Ė 1√¨g cloprostenol/kg BW and 5 √¨g cabergoline/kg BW.

The owner administered oral doses of cabergoline daily and a veterinarian injected the PGF2√°-agonist intramuscularly every second day in the clinic.

Treatment terminated pregnancy in all dogs (n = 20): 2 of them exhibited abortion, 6 bitches showed abortion of some foetuses as well as resorption of the remaining ones, but resorption of all foetuses took place in 12 cases. Side effects of the treatment decreased with reduced alfaprostol dose.

All group-A bitches vomited after each application of alfaprostol, in contrast to group C: 2 animals showed no side effects and only one bitch vomited after each treatment. Side effects were also alleviated in group B, when compared with group A.

In general, the animals responded to cloprostenol by exhibiting more serious side effects (group D) than in all other groups. Combined application of 5 ìg alfaprostol/kg BW and 5 ìg cabergoline/kg BW is able to terminate unwanted pregnancies in the bitch.

Treatment can be started when pregnancy is first detected by sonography. Advantages of the use of the tested medication in veterinary practice are high efficacity as well as mild side effects.

Source: www.fecava.org


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