Twenty-five WB horses from one farm underwent complete neurologic and ophthalmic examinations and serum α-TP concentrations were assessed.
Two of the most severely ataxic horses were euthanized and postmortem examinations performed.
Alpha-TP deficiency was widespread on this farm (22 of 25 horses).
Eleven of 25 horses were clinically normal (age range 2–12 years), one had signs of EMND (6 years of age), 10 had signs of ataxia consistent with NAD/EDM (1–10 years), and two of these were postmortem confirmed concurrent NAD/EDM and EMND.
A pigment retinopathy characterized by varying amounts of granular dark pigment in the tapetal retina was observed in four clinically apparent NAD/EDM horses (two postmortem confirmed concurrent NAD/EDM and EMND) and one horse with clinical signs of EMND.
A pigment retinopathy can be present in young α-TP-deficient Warmblood horses with clinical signs of EMND as well as those with signs of NAD/EDM.
Source: Finno, C. J., Kaese, H. J., Miller, A. D., Gianino, G., Divers, T. and Valberg, S. J. (2017), Pigment retinopathy in warmblood horses with equine degenerative myeloencephalopathy and equine motor neuron disease. Veterinary Ophthalmology, 20: 304–309. doi: 10.1111/vop.12417
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