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Carmustine instead of cyclophosphamide in canine lymphoma
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The combination of vincristine, prednisone and cyclophosphamide is one of most popular treatment protocols for canine malignant lymphoma. In this recently published study, cyclophosphamide was replaced by carmustine which is a nonphase-specific alkylating agent. Marked neutropenia was one of its main side effects.
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Six of the seven dogs treated with the carmustine-vincristine-prednisone protocol achieved complete remission (85,7%), one a partial remission.
The median survival time was 224 days, the median duration of remission 183 days.
No significant alteration of the platelets and the erythrocytes and no abnormalities in biochemical profiles were noted during therapy. A marked neutropenia after carmustine application was observed.
Thus, carmustine is an effective alternative in the treatment of canine malignant lymphoma.
Source: Ricci Lucas SR et al (2004): Carmustine, vincristine and prednisone in the treatment of canine lymphosarcoma. In: JAAHA 40:§, pp 292-299
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