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Familial diabetes mellitus in Samoyed dogs
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Diabetes mellitus is a common disease in middle aged and older dogs. Not too much is known about a genetic background. In this study, five closely related Samoyed dogs developed this disease suggesting that there might be a familial predisposition of diabetes mellitus at least in this breed.
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Five adult Samoyed dogs from two unrelated litters were diagnosed with diabetes mellitus.
Two full-sibling male dogs (Family A) were raised in the same household.
The other three dogs, two female and one male, were also full siblings (Family B) raised in different households.
All five dogs developed polyuria and polydipsia and demonstrated fasting hyperglycemia and glucosuria.
Diabetes mellitus was diagnosed in all five dogs and responded to appropriate therapy with insulin.
The occurrence of insulin-dependent diabetes mellitus in multiple, closely related Samoyed dogs suggests a familial predisposition in this breed.
Source: Susan E. Kimmel, Cynthia R. Ward, Paula S. Henthorn, Rebecka S. Hess (2002): Familial Insulin-Dependent Diabetes Mellitus in Samoyed Dogs. In: Journal of the American Animal Hospital Association 38:235-238 (2002)
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