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Sex hormone intermediates in dogs with alopecia
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Alopecia in dogs in often induced by hormonal imbalances, e.g. hypothyroidism or hyperadrenocorticism. But what if these are excluded? Steroid and sex hormone intermediates are sometimes measured. But: This study shows, that the evaluated parameters show significant breed-specific variations and `breed specific normal values` would be needed.
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The purpose of this study was to determine if there are specific steroid hormone aberrations associated with suspect endocrine alopecias in dogs in whom hypothyroidism and hyperadrenocorticism have been excluded.
Steroid hormone panels submitted to the UTCVM endocrinology laboratory over a 7.5-year period (783 samples) from dogs with alopecia were reviewed.
During this period, 276 dogs met the criteria for inclusion and were comprised of 54 different breeds.
Approximately 73% of dogs had at least one baseline or post-ACTH stimulation steroid hormone intermediate greater than the normal range.
The most frequent hormone elevation noted was for progesterone (57.6% of samples). When compared with normal dogs, oestradiol was significantly greater in Keeshond dogs and progesterone was significantly greater in Pomeranian and Siberian Husky dogs.
Not all individual dogs had hormone abnormalities. Chow Chow, Samoyed and Malamute dogs had the greatest percentage of normal steroid hormone intermediates of the dogs in this study.
Baseline cortisol concentrations were significantly correlated with progesterone, 17-hydroxyprogesterone (17-OHP) and androstenedione.
Results of this study suggest that the pathomechanism of the alopecia, at least for some breeds, may not relate to steroid hormone intermediates and emphasizes the need for breed specific normals.
Source: Frank, Linda A., Hnilica, Keith A., Rohrbach, Barton W. & Oliver, Jack W. (2003)
Retrospective evaluation of sex hormones and steroid hormone intermediates in dogs with alopecia. In: Veterinary Dermatology 14 (2), 91-97
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