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Drontal® Puppy
brochure-drontal-puppy.jpg A single dose wormer designed specifically for puppies and young dogs up to one year of age.

Active Ingredient
Febantel; Pyrantel embonate

Category
Endoparasitizides

Target Species
Dog

Mode of Action
Pyrantel embonate: Pyrantel, an anthelmintic of the tetrahydropyrimidine group of compounds, acts in a similar way to levamisol, by inducing a depolarising neuromuscular blockade. Pyrantel, being a cholinergic agonist, acts as an excitatory neurotransmitter at the nicotinergic receptor causing spastic pralysis of the parasite. The embonate salt of pyrantel is poorly soluble in water, which offers the advantage of reduced absorption from the gut, allowing the drug to express its high nematocidal efficacy directly within the digestive tract. Febantel: The mechanism of action of febantel is primarily based on interference with the carbohydrate metabolism of the worm. The suppression of mitochondrial reactions (inhibition of fumarate reductase) and interferencewith glucose transport act not only on all developmental stages of the helminths but also on the eggs containing the larvae. Benzimidazoles bind to the structural protein tubulin, thereby preventing its polymerization to microtubules which provide the transport system for the absorbing cells. The consequence of blocking this transport activity is incomplete absorption and digestion of nutrient particles and cellular autolysis through activation of lysosomal enzymes.

Indication/Description
Febantel: Dimethyl [[2-[(methoxyacetyl)amino]-4-(phenylthio)phenyl]carbonimidoyl] biscarbamate (CAS-No. 58306-30-2) Pyrantel embonate: (E)-1,4,5,6-tetrahydro-1-methyl-2-[2-(2-thienyl)ethenyl]pyrimidine and 4,4`-methylenebis[3-hydroxy-2-naphthalenecarboxylic acid (1:1) (CAS-No. 22204-24-6) ; DRONTAL PUPPY Suspension has a wide nematocidal spectrum of activity which covers infection with the following canine worm species: Ascarids: - Toxocara canis - Toxascaris leonina Hookworms: - Ancylostoma caninum - Uncinaria stenocephala Whipworms: - Trichuris vulpis

Chemical Structure

Pyrantel embonate:

picture - chem_structure_pyra3

Febantel:

picture - chem_structure_feba2

Method of Administration
The suspension is administered orally to the animal, either directly into the dog`s mouth with the calibrated syringe or mixed with food. No special dietary measures are required either in young dogs or in puppies. The product is given as a single dose (administration over several days is not necessary).

Dosage
1 ml per 1 kg bodyweight


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