Imidacloprid: chloronicotinyl nitroguanidine Permethrin: type I class of pyrethroide
Mode of Action
Imidacloprid: has a high affinity for the nicotinergic acetylcholine receptors in the post-synaptic region of the central nervous system (CNS) in insects. The ensuing inhibition of cholinergic transmission in insects results in paralysis and death of the parasite. Permethrin: Pyrethroids affect the voltage-gated sodium channels. Pyrethroids are so called `open channel blockers` affecting the sodium channel by slowing both the activation and the inactivation properties. This leads to a stable hyperexcitation state which induces a progressive development of fine whole-body tremors, exaggerated startle responses, incoordinated twitchings of dorsal muscles, hyperexcitability and death of the parasite.
Topical prevention and treatment of ticks, fleas and mosquitoes for monthly use on dogs and puppies 7 weeks of age and older.
Imidacloprid: CAS-No.: 138261-41-3 Permethrin: CAS-No.: 52645-53-1
Imidacloprid: 1-(6-Chloro-3-pyridylmethyl)-N-nitro-imidazolidin-2-ylideneamine Permethrin: 3-phenoxyphenyl)methyl 3-(2,2-dichloroethenyl)-2,2-dimethyl-cyclopropane carboxylate
topical, spot-on solution
Method of Administration
Part the hair on the dog`s back, between the shoulder blades, until the skin is visible. Place the tip of the tube on the skin and squeeze the tube twice to expel the entire contents directly to the skin.
Minimum dose:0.1 ml of solution per 1 kg body weight. Dosage: 10 mg/kg body weight imidacloprid and 50 mg/kg body weight permethrin
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