FIRST REPORT OF ACHROMATOPSIA IN RELATED LABRADOR RETRIEVER WITHOUT CNGB3 MUTATIONS
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Achromatopsia was identified in three Labrador Retriever littermates. The dogs demonstrated day blindness, negotiating obstacles under low-light conditions, but apparently blind when outdoors. The results of the ophthalmoscopy and the DNA Screening are very interesting!
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One of the dogs presented with immature bilateral diffuse posterior cortical cataracts and clinical signs of day blindness became apparent following cataract extraction surgery.
Electroretinography demonstrated an absence of a cone photoreceptor response to a bright stimulus and a flicker response of 30 Hz in all three dogs.
No fundic lesions have been apparent ophthalmoscopically in any of the dogs as the initial presentation of each case.
No abnormalities were detected with DNA screening for known mutations of the CNGB3 gene in any of the dogs.
Source: Dixon, C. J. (2015), Achromatopsia in three sibling Labrador Retrievers in the UK. Veterinary Ophthalmology. doi: 10.1111/vop.12265
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