Oral mucosal biopsies were collected from six dogs that died (n = 1) or were euthanized (n = 5) for reasons unrelated to this study.
The breeds included were two Doberman Pinschers, one Labrador Retriever, one Portuguese Water Dog, one German Shepherd Dog, and one mixed canine.
Three were spayed females, and three were castrated males with the median age of 9 years (range, 6–13 years).
Samples were obtained by an 8-mm punch biopsy at the following locations of the canine oral cavity: upper rostral labial mucosa at midline, lower rostral labial mucosa at midline, upper labial mucosa near the commissure, lower labial mucosa near the commissure, and buccal mucosa approximately 1 cm caudal to the commissure.
Samples were routinely processed with hematoxylin and eosin, and periodic acid–Schiff stains. Samples were evaluated by light microscopy.
At the selected locations, no MSG or other secreting cells were detected.
Minor salivary glands are not associated with alleviation of canine KCS symptoms following labial mucosa transplantation.
Further studies are needed to determine the mechanism leading to the transient improvement of KCS symptoms in canine patients following labial mucosa transplantation.
Source: Cherry, R. L., Smith, J. D. and Ben-Shlomo, G. (2018), Canine oral mucosa evaluation as a potential autograft tissue for the treatment of unresponsive keratoconjunctivitis sicca. Veterinary Ophthalmology, 21: 48–51. doi: 10.1111/vop.12477
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