The study was performed in two periods.
Four different OBs were tested.
Hundred grams of OB contained the following: OB-A: 35.17 g liquid paraffin (lp), 64.83 g white petrolatum (wp); OB-B: 10.03 g lp, 84.95 g wp 5.02 g lanolin; OB-C: 18.34 g lp, 51.40 g wp, 25.00 mg KH2PO4, 57.00 mg K2HPO4, 18.90 g eucerinum anhydricum, 11.28 g water for injections; and OB-D: 70 g unguentum lanalcoli, 20 g lp, 10 g aqua conservans.
One eye was treated, and the other served as a negative control.
Cats received the OBs TID for 28 days.
The two study periods were separated by a 4-month washout phase.
Samples for conjunctival impression cytology, swabs for bacteriologic and mycologic examination, and cytobrush samples for FHV-1 and Chlamydophila felis PCR detection were obtained.
Both eyes were examined daily.
Severity of ocular symptoms was scored using a modified Draize eye irritation test.
A total of five eyes were treated with OB-A, five with OB-B, four with OB-C, and five with OB-D.
Treated eyes had significantly higher clinical scores.
Eyes receiving OB-A had the highest overall clinical score.
The results of bacteriologic and mycologic examination concur with the previously published data.
All samples tested were negative for FHV-1 and Chlamydophila felis.
There was no significant difference between treated and control eyes upon cytological examination.
The application of OBs resulted in clinical symptoms in treated eyes.
The long-term use of ointments is not well tolerated in cats and may lead to ocular irritation.
Source: Eördögh, R., Schwendenwein, I., Tichy, A., Loncaric, I. and Nell, B. (2015), Clinical effect of four different ointment bases on healthy cat eyes. Veterinary Ophthalmology. doi: 10.1111/vop.12279
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