Bilateral patients received bromfenac or celecoxib-IOL plus PA in one eye, and PA in the contralateral eye.
Unilateral patients received bromfenac or PA. Complete ophthalmic examination including tonometry, slit-lamp grading of flare and PCO, and digital image acquisition for masked PCO evaluation was performed within 24 h and 1, 4, 12, 24, and 56 weeks following surgery.
Celecoxib-IOL/PA-treated eyes had significantly less flare than PA-treated eyes, which had significantly less flare than bromfenac-treated eyes 24 h postoperatively.
There was no significant difference in intraocular pressure (IOP) postoperatively, or at 1, 24, or 56 weeks.
Celecoxib-IOL/PA-treated eyes had significantly lower IOP measurements than bromfenac and PA-treated eyes at 4 and 12 weeks.
There was no significant difference in PCO level between groups using slit-lamp biomicroscopy at any time point.
Masked evaluation of digital images revealed significantly less PCO in celecoxib-IOL/PA- vs. bromfenac-treated eyes at 4 weeks, and in bromfenac- vs. PA-treated eyes at 56 weeks.
Eyes receiving celecoxib-IOL/PA had better initial control of inflammation.
Bromfenac was equally effective compared with PA in controlling inflammation.
There was no association between COX-2 inhibitor administration and ocular hypertension.
Celecoxib-IOL/PA-treated eyes showed better initial control of PCO (up to 12 weeks), while eyes receiving bromfenac had better long-term control of PCO (56 weeks).
Source: Brookshire, H. L., English, R. V., Nadelstein, B., Weigt, A. K., Gift, B. W. and Gilger, B. C. (2015), Efficacy of COX-2 inhibitors in controlling inflammation and capsular opacification after phacoemulsification cataract removal. Veterinary Ophthalmology, 18: 175–185. doi: 10.1111/vop.12159
|