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Dermatology Home DERMATOLOGY
OSTEOLYTIC OSTEOMYELITIS IN A DOG WITH VISCERAL LEISHMANIASIS
Leishmaniasis can mimic nearly every cutaneous or extracutaneous disease, as everybody knows. Here is a very fascinating case report from Brazil where the affected dog showed weight loss and lameness of a hindleg - not very specific for any disease...

A dog was examined with a history of weight loss and lameness of the left hind limb.

A painful response to examination of the left hip joint, and lymphadenopathy were noted.

Amastigote forms of Leishmania sp. were observed by cytology in samples from the popliteus lymph node, and anti-Leishmania sp. antibodies at a titer of 1:640 were detected in serum by indirect immunofluorescence.

Radiological changes included osteolysis and a periosteal proliferative reaction in the left femoral greater trochanter.

These changes were histologically characterized as an osteolytic granulomatous osteomyelitis associated with amastigotes within macrophages.

Non-decalcified fragments of the periosteum were processed for immunohistochemistry, observed with prominent immunolabelling of amastigotes of Leishmania sp. within macrophages.

The diagnosis was further confirmed by positive PCR for Leishmania sp., belonging to the Leishmania donovani complex.



Source: de Souza AI, Juliano RS, Gomes TS, de Araujo Diniz S, Borges AM, Tafuri WL, Santos RL. (2005):Osteolytic osteomyelitis associated with visceral leishmaniasis in a dog. In: Vet Parasitol. 2005 Apr 20;129(1-2):51-4.


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... hautnah dran
Efficacy of three different antiseptics as surgical skin preparations in dogs Various antiseptics are available for surgical skin preparation. The objective of this new study for South Africa was to compare the antimicrobial efficacy of a 2% chlorhexidine gluconate and 70% ethanol solution (CG+A) with that of F10 Skin Prep Solution (F10) and electrochemically activated water (EAW) when used as a surgical preparation in canine patients. One hundred sixteen dogs presented for ovariohysterectomy were enrolled in this prospective randomized clinical study very important for daily surgical practice.

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