|Surgical incision of the prepuce skin of the anaesthetized dogs showed the presence of single pedunculated, soft, pink-red, cauliflower-like masses arising from the penile mucosa, with diameter ranging from 2 to 8 cm.
In all cases, histopathological examination of the excised masses showed normal epithelial differentiation with digitiform expansion of all the layers and elongated rete ridges slanted towards the periphery of the lesion.
Evidence of ballooning degeneration or basophilic intranuclear inclusion bodies was not found.
Both immunohistochemistry and polymerase chain reaction techniques failed to reveal papillomavirus.
According to the histological World Health Organization classification of papillomatous lesions and due to the lack of evidence of a viral origin the masses were identified as idiopathic mucosal penile squamous papillomas.
Urinary problems resolved after surgical excision, haematuria was therefore considered secondary to ulceration of the papillated masses.
Source: Luisa Cornegliani, Antonella Vercelli, Francesca Abramo (2007): Idiopathic mucosal penile squamous papillomas in dogs. In:
Veterinary Dermatology 18 (6), 439Â–443.