|Five dogs with end-stage proliferative otitis externa were included in this study (one Golden Retriever, four Cocker Spaniels) which were referred for total ear canal ablasion.
They were treated with Cyclosporin A (5 mg/kg BID) for at least 12 weeks.
All dogs showed significant clinical improvement with a much better life quality and an increasing diameter of the stenotic ear chanel. None of the dogs had to go to surgery.
The results of this small group indicate that cyclosporin A might be a good alternative to surgery in canine end stage otitis externa, but a larger study would be indicated to confirm these findings.
Source: Hsll, J.A., Waisglass, S.E., Mathews, K.A., Tait, J.L. (2003): Oral cyclosporin in the treatment of end-stage ear disease: a pilot study. In: Veterinary Dermatology 14, 2003, p 212