|In this study, we describe 20 horses with skin tumours similar to these naevi of humans. These tumours represented individual skin masses in male and female horses of different breeds.
Tumours resembling human intradermal common melanocytic naevi were noted in 12 horses aged between 2 and 17 years.
Seven horses aged between 4 and 15 years developed cutaneous lesions similar to human cellular blue naevi.
A combined cellular blue naevus-like tumour was diagnosed in a 20-year-old horse.
All tumour types formed expansile, well-demarcated, non-encapsulated, symmetrical masses.
Tumours similar to intradermal common melanocytic naevi were composed of nests of round and spindeloid neoplastic cells, often embedded in myxomatous stroma.
Lesions resembling cellular blue naevi were formed by intradermal bundles of ovoid to elongated cells separated by collagen fibres.
The combined cellular blue naevus-like tumour resembled human cellular blue naevus with in addition, an overlying junctional common melanocytic naevus.
Neoplastic cells in all groups contained varying amounts of melanin pigment and were immunopositive for S100.
These equine skin tumours differ from the commonly recognized equine melanocytic tumours by their cytomorphological features, random location and the absence of an increased tumour frequency in grey horses.
The resemblance of these tumours to three distinct subgroups of human naevi expands the complexity of equine proliferative cutaneous melanocytic lesions.
Source: Sandra SchÃ¶niger, Brian A. Summers (2009): Equine skin tumours in 20 horses resembling three variants of human melanocytic naevi. In: Veterinary Dermatology
Volume 20 Issue 3, Pages 165 - 173