Vetcontact
Bayer Novartis Boehringer-Ingelheim Virbac France
Vetcontact Events Presentations Posters Case Studies Speciality Organisations
CPD Forum Products Login/Newsletter
Dermatology Home DERMATOLOGY
LOW-DOSE SPECIFIC IMMUNOTHERAPY IN DOGS WITH ATOPIC DERMATITIS
Allergen-specific immunotherapy (ASIT) is an effective therapeutic option in canine atopic dermatitis. There are anecdotal reports of increased effectiveness of ASIT in dogs with doses of vaccine lower than that recommended by the manufacturers. However, no controlled studies have been carried out before...

The aim of this prospective, double-blinded study was to evaluate whether induction and maintenance with low dose (LD) ASIT resulted in a different success rate compared with the standard dose (SD).

Twenty-seven dogs with confirmed atopic dermatitis were allocated by block randomization to two groups. One group (n = 13) received SD ASIT; the other group (n = 14) received LD ASIT (1/10 of the SD) following the same frequency protocol.

Cases were graded at 0, 3, 6 and 9 months for clinical signs using a modified canine atopic dermatitis extent and severity index (mCADESI) and for pruritus using a 0-5 descriptor scale.

There were no significant differences between the groups in the pruritus and mCADESI scores (P > 0.155) at the end of the study, and the changes in pruritus (P > 0.920) and mCADESI (P > 0.296) scores from the beginning to the end of the study were similar in both groups. Pruritus scores in both groups did not change during the study (P > 0.052).

However, significant reductions in mCADESI scores were seen in both groups (P < 0.032).

Six dogs achieved a final pruritus score of 0, six achieved a reduction in pruritus score and 15 did not improve or worsened.

There was, therefore, no evidence that LD ASIT is more effective than the standard protocol.



Source: Colombo S, Hill PB, Shaw DJ, Thoday KL. (2005): Effectiveness of low dose immunotherapy in the treatment of canine atopic dermatitis: a prospective, double-blinded, clinical study. In: Vet Dermatol. 2005 Jun;16(3):162-70.



Tell a friend   |   Print version   |   Send this article

... hautnah dran
Inguinal percutaneous ultrasound to locate cryptorchid testes in horses Standing laparoscopic removal of abdominally retained cryptorchid testes may reduce patient morbidity and speed recovery compared with traditional laparotomy because anaesthesia is avoided and skin incisions are smaller. Reliably locating the testis preoperatively is therefore optimal to avoid unnecessary surgical morbidity and expense. The authors describe and review the results of a simple method of location using ultrasound scanning of the inguinal region, with a negative result indicating abdominal Retention, developed on more than 170 horses.

  • Transcriptome analysis of sarcoids in horses
  • Atopic dermatitis and the intestinal microbiota in dogs and men
  • 2-tier histologic grading system for canine cutaneous mast cell tumors on cytology
  • Atopic dermatitis and the intestinal microbiota
  • Axial pattern skin flaps in dogs and cats - indications, complications, results
  • Ocular changes in Quarter horses with hereditary equine regional dermal asthenia
  • Aseptic preparation of the skin before arthrocentesis in horses
  • Steroid sparing effect of essential fatty acid supplementation
  • Transdermal methimazole for treatment of feline hyperthyroidism
  • Biophysical evaluation for mapping of the canine skin
  • Do cellular blue naevi exist in horses?
  • New insights in the pathogenesis of equine sarcoids
  • Bandaging and second intention wound healing in horses with distal limb wounds
  • Multinodular pulmonary fibrosis in horses due to Herpes infection
  • Topical treatment of equine cannon hyperkeratosis
  • Masitinib in canine mast cell tumors
  • Low dose cyclosporin plus ketoconazole in canine perianal fistulas
  • Multinodular pulmonary fibrosis in horses due to Herpesvirus infection
  • Allergen threshold concentrations in equine intradermal testing
  • Ultrasound-guided removal of superficial plant awns
  • Correlation between parasite load in facial skin and tributary lymph nodes in Leishmaniasis
  • Program for global eradication of foot-and-mouth-disease
  • Quantification of lumpy skin disease virus after experimental infection
  • Laser surgery in canine interdigital cysts and comedones
  • Gene transcription in canine atopic dermatitis
  • Idiopathic papillomas of the penile mucosa
  • Update of the aetiology of canine otitis externa
  • 0.4% topical stannous fluoride gel for bacterial skin infections in horses
  • 0.1% tacrolimus ointment (Protopic┬«) in canine atopic dermatitis
  • Suppurative facial cellulitis and panniculitis caused by Corynebacterium pseudotuberculosis
  • In vitro model of Microsporum canis dermatophytosis
  • Latent viral phase in horses with sarcoids?
  • Misuse of statistics in veterinary dermatology
  • Subcutaneous abscess with severe complications due to Clostridium perfringens
  • Papillomaviral sequences in feline Bowenoid in situ carcinoma
  • Dermatitis due to Dermanyssus gallinae in a horse
  • Intraepidermal adenocarcinoma in the perianal skin of two cats
  • Generalized alopecic and cystic dermatosis in a cat (case report)
  • Proliferative and necrotizing otitis externa in cats
  • Malassezia overgrowth in allergic cats
  • Cutaneous reactive histiocytosis in dogs
  • Skin fragility syndrome associated with FIP (case report)
  • Multiple cutaneous ganglioneuromas in a Labrador retriever (case report)
  • Reconstruction of the lower eyelid in cats with squamous cell carcinoma
  • Transposition of first digital pad for reconstruction of a soft tissue defect (case report)
  • Advances in mast cell tumour diagnosis and therapy
  • Facial staphylococcal-associated dermatitis in sheep
  • Pyotraumatic dermatitis - new insights
  • Sugars in surface microbe-host interactions
  • Six organic diseases mimicking acral lick dermatitis
  • First artificial living skin graft produced
  • Imidacloprid/moxidectin combination against naturally acquired canine scabies
  • New insights in equine anhidrosis
  • Congenital lipoblastoma in a neonate calf
  • Raccoonpox infection in a cat in Canada (case report)
  • Selamectin against Psoroptes and Sarcoptes mites in rabbits
  • Canine pyoderma caused by Pseudomonas aeruginosa infection
  • Raccoonpox infection in a cat (case report)
  • Alopecia and dermatopathy after pelvic fractures
  • Ciprofloxacin instead of enrofloxacin in disk diffusion susceptibility test (DDT)?
  • Objective measurement of pruritus in dogs
  • Regional differences in the drug penetration through equine skin
  • Mast cells and angiogenesis in canine melanomas - prognostic factors
  • Home-made versus chicken hydrolysate diet in dogs with adverse food reactions
  • Imiquimod 5% cream in equine sarcoids
  • Plant extracts in the treatment of canine atopic dermatitis
  • Lifestyle factors taking influence on the prevalence of allergies in children
  • Feline cutaneous mycobacteriosis - which subtypes are the most common?
  • Equine Culicoides Hypersensitivity: Update of tests
  • News from the external ear canal of horses
  • Recombinant canine interferon-alpha (KT-100) versus antihistamines in atopic dogs
  • Zygomatic salivary cyst with mucocele in a cat
  • Long-term results of immunosuppressive therapy in canine pemphigus foliaceus
  • Feline acne - an update
  • Results of vulvoplasty in 34 dogs with recessed vulva
  • Osteolytic osteomyelitis in a dog with visceral leishmaniasis
  • Immunolocalization of aquaporin-5 expression in sweat gland cells of horses
  • Canine dermatitis due to Straelensia cynotis (case report)
  • Encephalitozoon hellem infection causing an unilateral chronic keratoconjunctivitis in an umbrella
  • Efficacy and safety of cyclosporin in dogs with atopic dermatitis
  • Colorectal plasmocytomas - how do they behave?
  • Therapy-refractory pododermatitis - a novel disease?
  • Pustular calicivirus dermatitis on the abdomen of two cats after routine ovariectomy
  • Selamectin against Rhipicephalus sanguineus and Dermacentor variabilis
  • Oral doxycycline, niacinamide and prednisolone in bilateral nodular granulomatous conjunctivitis
  • Atopy patch test reactions in high-IgE beagles
  • Topical eprinomectin in the treatment of Psoroptes cuniculi
  • Exfoliative toxins from Staphylococcus hyicus
  • S-Adenosyl-L-Methionine (SAMe) as antidote in acetaminophen toxicity
  • Itraconazole pulse therapy in dogs with malassezia dermatitis
  • Prevalence of house dust mite-antigen in houses with and without dogs
  • Skin myxoma in a dog (case report)
  • Bilateral ear canal neoplasia in dogs
  • Doramectin against scabies in rabbits
  • Intermediate steroid hormone levels in dogs with Alopecia X
  • Skin metastases of a bronchial adenocarcinoma in a cat (case report)
  • Zinc-responsive probably hereditary dermatosis in goats
  • Metabolism of progesterone by canine hair follicle cells (In vitro)
  • Leishmania spp. and Mycobacterium spp. in canine cutaneous `sterile` pyogranuloma/granuloma syndrome
  • Manifestations of exfoliative cutaneous lupus erythematosus in German short-haired pointers
  • Different serum immunoreactivity to Malassezia pachydermatis in dogs
  • Immunostimulatory liposome-nucleic acid complexes in allergen-specific immunotherapy of dogs with AD
  • ... and the winners are:
  • Hereditary regional dermal asthenia in three Brazilian Quarter horses
  • Terbinafine versus ketoconazole in canine malassezia dermatitis
  • Are human and canine staphylococci species specific?
  • Castration and gestagen therapies in male dogs
  • Heat shock proteins expression in canine skin tumors
  • Role of IgE in equine urticaria
  • Acral mutilation and analgesia in French spaniels
  • Rapidly growing Mycobacteria in dogs and cats
  • Cutaneous neosporosis in a dog with pemphigus foliaceus
  • Intravenous fluorescein in intradermal allergy testing in birds
  • Prevalence of house dust mite allergens in the UK
  • Adult-onset hair loss in Chesapeake Bay retrievers
  • Efficacy of various therapies in canine atopic dermatitis
  • Do eczema drugs increase the risk of cancer?
  • Cutaneous microflora in horses with and without skin diseases
  • Topical pimecrolimus in canine KCS
  • Immunohistochemistry in dogs with VKH-like syndrome
  • Only every fifth dog had known tick exposure
  • Clindamycin once daily in canine pyoderma
  • Pyotraumatic dermatitis: new insights in histopathology
  • Bacteria isolates from skin and ears over 6 years
  • `Food allergens` of lamb, beef and cow┬┤s milk identified?
  • Seasonal insect bite hypersensitivity in sheep
  • Do we use the wrong allergen concentrations for intradermal skin testing?
  • Corynebacterium pseudotuberculosis outbreak causes skin lesions and mastitis
  • Prednisone or prednisolone in the feline patient?
  • Superficial necrolytic dermatitis in a cat: diagnostic findings (case report)
  • Cephalexin intermittent therapy in dogs with ┬ôidiopathic┬ö recurrent pyoderma
  • Patch tests with house dust mite antigen in dogs
  • Intradermal or allergen-specific IgE tests in seasonal atopic dermatitis?
  • Are Malassezia yeasts the reason for feather picking?
  • Essential fatty acids in canine atopic dermatitis
  • Canine distemper virus in epidermis of the footpads
  • Sex hormone intermediates in dogs with alopecia
  • Synergistic effect of chlorhexidine and miconazole on M. canis growth in vitro
  • Oral cyclosporin in canine end stage otitis
  • Dermoid cyst in the dorsal midline of a young horse (case report)
  • Topical 0,1% tacrolimus in canine atopic dermatitis
  • `Irritant` threshold concentration for insect extracts in equine skin testing
  • Pelvic fractures and the skin
  • Research project for equine hereditary diseases started
  • Update in treatment of dermatophytosis in dogs and cats
  • Hand and forearm dermatoses in veterinarians
  • Preoperative warming to reduce wound infections?
  • Interdigital dermatitis - update in therapeutic options
  • Intradermal allergy test in psittacines: unreliable with and without intravenous fluorescein
  • Coma and apnea in a dog with hydroxyzine toxicosis (case report)
  • Efficacy of terbinafine and ketoconazole against Malassezia in dogs
  • New technique for skin biopsies in birds
  • Skin Biology and Innovations in Dermatology



  • [ Home ] [ About ] [ Contact / Request ][ Disclaimer ]

    Copyright © 2001-2016 VetContact GmbH
    All rights reserved