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Dermatology Home DERMATOLOGY
TOPICAL 0,1% TACROLIMUS IN CANINE ATOPIC DERMATITIS
Topical tacrolimus is commonly used in men with atopic dermatitis, especially in children. It offers many advantages compared with topical corticosteroids, showing similar results but less topic and systemic side effects. Is this drug also a good alternative in veterinary medicine?

In this study, efficacy and safety of 0,1% tacrolimus were evaluated. The 12 dogs either received 0,1% tacrolimus (Protopic) or placebo for 4 weeks, and after another 2 weeks the groups were switched for another 4 weeks.

Clinical signs were evaluated using a modified CADESI score. Blood samples for CBC, serum biochemistry and tacrolimus concentrations were taken at week 0 and 4 of each treatment.

Tacrolimus significantly decreased the severity of symptoms for both investigators and owners. No adverse effects were seen, and no changes in CBC and serum biochemistry between groups or within groups were seen.

According to these results, tacrolimus seems to be a safe altenative treatment in dogs with atopic dermatitis.

Source: Marsella, R., Nicklin, C.F., Saglio, S., Lopez, J. (2003): Investigation in efficacy and safety of 0,1% tacrolimus ointment (Protopic R) in in canine atopic dermatitis: a randomized, double-blinded, pacebo-controlled, cross-over study. In: Veterinary Dermatology 14 (4), p 213

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... hautnah dran
Inguinal percutaneous ultrasound to locate cryptorchid testes in horses Standing laparoscopic removal of abdominally retained cryptorchid testes may reduce patient morbidity and speed recovery compared with traditional laparotomy because anaesthesia is avoided and skin incisions are smaller. Reliably locating the testis preoperatively is therefore optimal to avoid unnecessary surgical morbidity and expense. The authors describe and review the results of a simple method of location using ultrasound scanning of the inguinal region, with a negative result indicating abdominal Retention, developed on more than 170 horses.

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