|Twenty-two infected dogs with and without signs of infection were examined to demonstrate correlation of signs with parasite load and the correlation of facial skin lesions with parasites in regional lymph nodes.
Chronic inflammation of the skin was demonstrated in infected dogs that had no gross skin lesions, confirming that normal-appearing skin can harbor the parasite, likely playing a role in transmission.
Dogs with facial skin lesions showed a higher parasite load in parotid lymph nodes than dogs without lesions of the facial skin, based on Leishman-Donovan unit analysis.
Based on immunohistochemical analysis, parasite load in parotid and cervical nodes was correlated with that of skin of the nose and pinna, as was the parasite load in mandibular lymph nodes and skin of the external nose.
We demonstrated a logical involvement of the lymphatic vessels and their specific anatomic draining sites.
Source: M. M. S. Costa, W. G. Lima, M. M. Figueiredo, M. S. M. Michalick, W. L. Tafuri and W. L. Tafuri (2008): Cervical, Mandibular, and Parotid Lymph Nodes of Dogs Naturally Infected with Leishmania infantum: A Histopathologic and Immunohistochemistry Study and Its Correlation with Facial Skin Lesions. In: Vet Pathol 45:613-616 (2008)